Please be advised that I have the exact same issue with Exchange 2010 on Server 2009 R2 (single server single domain), the results are always after MSExchangeIS activity as follows:
Exchange Server GUID per Get-ExchangeServer | fl Guid:
24eb06e9-4a9b-4f14-b5f6-5b9528b8ce65
GUID as per the event 8365 text:
E906EB249B4A144FB5F65B9528B8CE65
this must be a "bug", no losss of funtion perceived!!!
.......but needs fixing.